Necessity for LH in selection and continued growth of the bovine dominant follicle

in Reproduction
Authors:
Victor E Gomez-León Eutheria Foundation, Cross Plains, Wisconsin, USA
Department of Dairy Science, University of Wisconsin-Madison (UW-Madison), Madison, Wisconsin, USA
Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa, Brazil

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O J Ginther Eutheria Foundation, Cross Plains, Wisconsin, USA
Department of Pathobiological Science, School of Veterinary Medicine, UW-Madison, Madison, Wisconsin, USA

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Rafael R Domingues Eutheria Foundation, Cross Plains, Wisconsin, USA
Department of Pathobiological Science, School of Veterinary Medicine, UW-Madison, Madison, Wisconsin, USA

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José D Guimarães Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa, Brazil

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Milo C Wiltbank Department of Dairy Science, University of Wisconsin-Madison (UW-Madison), Madison, Wisconsin, USA

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Correspondence should be addressed to M C Wiltbank; Email: wiltbank@wisc.edu
DOI:
https://doi.org/10.1530/REP-19-0342
Volume/Issue:
Volume 159: Issue 5
Page Range:
559–569
Article Type:
Research Article
Online Publication Date:
May 2020
Copyright:
© 2020 Society for Reproduction and Fertility 2020
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Previous research demonstrated that acute treatment with GnRH antagonist, Acyline, allowed follicle growth until ~8.5 mm and no dominant follicle was selected. This study evaluated whether deficient LH was the underlying mechanism for Acyline effects by replacing LH action, using human chorionic gonadotropin (hCG), during Acyline treatment. Holstein heifers (n = 24) during first follicular wave were evaluated by ultrasound and randomized into one of three treatments: Control (saline treatments), Acyline (5 µg/kg Acyline), or Acyline+hCG (Acyline plus 50 IU of hCG at start then 100 IU every 12 h). Pulses of LH were present in Control heifers (9 Pulses/10 h) but not during Acyline treatment. Data were normalized to the transition to diameter deviation (day 0; F1 ~7.5 mm). Diameter deviation of the largest (F1) and the second largest (F2) follicle was not observed in Acyline-treated heifers, whereas control heifers had decreased growth of F2 at F1 ~7.5 mm, indicating deviation. Selection of a single dominant follicle was restored by providing LH activity in Acyline+hCG heifers, as evidenced by F1 and F2 deviation, continued growth of F1, and elevated circulating estradiol. Separation of F1 and F2 occurred 12 h (~7.0 mm) earlier in Acyline+hCG heifers than Controls. Circulating FSH was greater in Acyline than Controls, but lower in Acyline+hCG than Controls after day 1.5. In conclusion, dominant follicle selection and growth after follicle deviation is due to LH action as shown by inhibition of this process during ablation of GnRH-stimulated LH pulses with Acyline and restoration of it after replacement of LH action by hCG treatment.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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