Location relative to the corpus luteum affects bovine endometrial response to a conceptus

in Reproduction
Authors:
Sandra Bagés-Arnal School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland

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José M Sánchez School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland

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Beatriz Fernandez-Fuertes Biotechnology of Animal and Human Reproduction (TechnoSperm), Department of Biology, Institute of Food and Agricultural Technology, University of Girona, Girona, Spain

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Michael McDonald School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland

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Susanta K Behura Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA

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Thomas E Spencer Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA

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Trudee Fair School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland

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https://orcid.org/0000-0002-5079-8589
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Pat Lonergan School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland

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Correspondence should be addressed to P Lonergan; Email: pat.lonergan@ucd.ie
DOI:
https://doi.org/10.1530/REP-19-0464
Volume/Issue:
Volume 159: Issue 5
Page Range:
643–657
Article Type:
Research Article
Online Publication Date:
May 2020
Copyright:
© 2020 Society for Reproduction and Fertility 2020
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In cattle, embryo transfer into the uterine horn contralateral to the corpus luteum results in a higher incidence of pregnancy loss compared to transfer into the ipsilateral horn. We have previously reported temporal changes in the endometrial transcriptome during the estrous cycle which differ between uterine horns. The objective of this study was to compare the transcriptomic response of endometrium from the ipsilateral and contralateral horns to an elongating conceptus. Cross-bred beef heifers (n = 16) were synchronized and either used to generate day 14 conceptuses following the transfer of in vitro-produced blastocysts or to obtain day 14 endometrial explants. Conceptuses were recovered on day 14 by post-mortem uterine flushing, placed individually on top of explants collected from the ipsilateral (IPSI-D14) or the contralateral (CONTRA-D14) uterine horn of cyclic heifers, and co-cultured for 6 h. The response to a conceptus was markedly different between uterine horns, with 61 and 239 differentially expressed genes (DEGs; false discovery rate <0.05) in the ipsilateral and contralateral horns, respectively, compared to their controls. Direct comparison between IPSI-D1 and CONTRA-D14 revealed 32 DEGs, including CXCL11, CXCL10, IFIT2, RSAD2 and SAMD9. Gene Ontology analysis of these 32 genes revealed ten enriched biological processes, mainly related to immune response and response to an external stimulus. These data indicate that the endometrial response to the presence of a conceptus varies between uterine horns in the same uterus and may contribute to the higher incidence of pregnancy loss following embryo transfer to the contralateral horn.

Supplementary Materials

    • Table S1. Logarithm of fold change (LogFC) in gene expression between IPSI-CTRL and ISPI-D14 endometrial explants
    • Table S2. Logarithm of fold change (LogFC) in gene expression between CONTRA-CTRL and CONTRA-D14 endometrial explants
    • Table S3. Biological processes significantly enriched in the list of differentially expressed genes (DEGs) between IPSI-CTRL and IPSI-D14 endometrial explants. (GO: Gene Ontology)
    • Table S4. Biological processes significantly enriched in the list of differentially expressed genes (DEGs) between CONTRA-CTRL and CONTRA-D14 endometrial explants. (GO: Gene Ontology)
    • Table S5. Logarithm of fold change (LogFC) in gene expression between ISPI-D14 and CONTRA-D14 endometrial explants. (FDR: False discovery rate)
    • Table S6. Biological processes significantly enriched in the list of differentially expressed genes (DEGs) between IPSI-D14 and CONTRA-D14 endometrial explants.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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