Telomeres and oocyte maturation rate are not reduced by COVID-19 except in severe cases

in Reproduction
Authors:
L Chico-Sordo IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain

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A M Polonio IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain

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I Córdova-Oriz IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain

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M Medrano IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain

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S Herraiz IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain

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F Bronet IVIRMA Madrid, Madrid, Spain

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J A García-Velasco IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain
IVIRMA Madrid, Madrid, Spain
Rey Juan Carlos University, Edificio Departamental II, Alcorcón, Madrid, Spain

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E Varela IVI Foundation, The Health Research Institute La Fe (IIS La Fe) – Edificio Biopolo, Valencia, Spain
Rey Juan Carlos University, Edificio Departamental II, Alcorcón, Madrid, Spain

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https://orcid.org/0000-0002-5361-3877

Correspondence should be addressed to E Varela; Email: Mariaelisa.Varela@ivirma.com
DOI:
https://doi.org/10.1530/REP-22-0243
Volume/Issue:
Volume 164: Issue 5
Page Range:
259–267
Article Type:
Research Article
Online Publication Date:
17 Oct 2022
Copyright:
© Society for Reproduction and Fertility 2022
Restricted access
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In brief

COVID-19 does not affect the telomeres or fertility outcomes in mild cases. However, in women with severe symptoms, telomeres of granulosa cells are shorter, and the oocyte maturation rate is decreased.

Abstract

The coronavirus SARS-CoV-2 causes COVID-19 disease and affects primarily the lungs and also other organs, causing accelerated cell aging. One of the main pathways involved in aging is telomere attrition, which ultimately leads to defective tissue regeneration and organ dysfunction. Indeed, short telomeres in aged people aggravate the COVID-19 symptoms, and COVID-19 survivors showed shorter telomeres in blood cells. The SARS-CoV-2 has been detected in testis, but the ovaries, which express the viral entry factors, have not been fully explored. Our objective was to analyze telomeres and reproductive outcomes in women who had COVID-19 and controls. In this prospective cohort study, granulosa cells (GCs) and blood were collected from 65 women. Telomere length (TL) was measured by high-throughput in situ hybridization. Mean TL of GCs and peripheral blood mononuclear cells (PBMCs) was alike in control and mild cases. However, mean TL of GCs was lower in severe cases compared to controls (P = 0.017). Control and COVID groups had similar ovarian reserve and number of total oocytes after puncture. However, the oocyte maturation rate was lower in severe cases (P =  0.018). Interestingly, a positive correlation between the oocyte maturation rate and TL of GCs was found in the control group (P = 0.024). Our findings point to a potential impact of the coronavirus infection on telomeres and reproductive outcomes in severe cases. This might be considered upon possible new SARS-CoV threats, to favor treatments that enhance oocyte maturation in women severely affected by coronavirus undergoing ART.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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