Alternating mealtimes during pregnancy and weaning triggers behavioral changes in adult offspring

in Reproduction
Authors:
Mi-Hee KimDepartment of Neuroscience, Graduate school, Kyung Hee University, Seoul, Korea

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Jihyun ParkDepartment of Neuroscience, Graduate school, Kyung Hee University, Seoul, Korea

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Dong-Hee HanDepartment of Neuroscience, Graduate school, Kyung Hee University, Seoul, Korea

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Jong-Yun NohDepartment of Neuroscience, Graduate school, Kyung Hee University, Seoul, Korea

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Eun-Sang JiDepartment of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea

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Sung-Ho LeeDepartment of Life Science, Sangmyung University, Seoul, Korea

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Chang-Ju KimDepartment of Physiology, Kyung Hee University School of Medicine, Seoul, Korea

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Sehyung ChoDepartment of Neuroscience, Graduate school, Kyung Hee University, Seoul, Korea
Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea

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https://orcid.org/0000-0003-1272-0139
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Correspondence should be addressed to S Cho; Email: sehyung@khu.ac.kr

*(M-H Kim and J Park contributed equally to this work)

DOI:
https://doi.org/10.1530/REP-22-0164
Volume/Issue:
Volume 165: Issue 1
Page Range:
135–146
Article Type:
Research Article
Online Publication Date:
12 Dec 2022
Copyright:
© Society for Reproduction and Fertility 2023
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In brief

Mealtime changes in pregnant mice revealed impaired neurobehavioral development in mouse offspring. This study is the basis for investigating diseases associated with neurobehavioral development of adult offspring of pregnant shift-working women.

Abstract

Most organisms on Earth have a biological clock, and their physiological processes are regulated by a 1-day cycle. In modern society, several factors can disturb these biological clocks in humans; in particular, individuals working in shifts are exposed to stark environmental changes that interfere with their biological clock. They have a high risk of various diseases. However, there are scarce experimental approaches to address the reproductive and health consequences of shift work in the offspring of exposed individuals. In this study, considering the fact that shift workers usually have their meals during their adjusted working time, we aimed to examine the effects of a 12-h shift with usual mealtime as a plausible night work model on the neurobehavioral development of adult mouse offspring. In these offspring, early exposure to this mealtime shift differentially affected circadian rhythmic variables and total locomotor activity depending on the timing and duration of restrictive feeding. Moreover, neurobehavioral alterations such as declined short-term memory and depressive-like behavior were observed in adulthood. These results have implications for the health concerns of shift-working women and their children.

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 55 55 7
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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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