High-lipid nutritional environment in different ontogenetic periods induce developmental programming of rat prostate at aging

in Reproduction
Authors:
Tatiane Pereira ScarpelliDepartament of Biological Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, São Paulo, Brazil

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Eloisa Zanin PytlowancivDepartament of Biological Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, São Paulo, Brazil
Department of Structural and Functional Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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Maria Etelvina Pinto-FochiDepartament of Biological Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, São Paulo, Brazil
Faculdade de Medicina, União das Faculdades dos Grandes Lagos (UNILAGO), São José do Rio Preto, São Paulo, Brazil

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Sebastião Roberto TabogaDepartament of Biological Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, São Paulo, Brazil

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https://orcid.org/0000-0002-0970-4288
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Rejane Maira GóesDepartament of Biological Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, São Paulo, Brazil

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Correspondence should be addressed to R M Góes; Email: rejane.goes@unesp.br
DOI:
https://doi.org/10.1530/REP-22-0258
Volume/Issue:
Volume 165: Issue 1
Page Range:
65–78
Article Type:
Research Article
Online Publication Date:
02 Dec 2022
Copyright:
© Society for Reproduction and Fertility 2023
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In brief

Maternal obesity plus high-fat diet in breastfeeding induces stromal hyperplasia and diffuse acinar atrophy in the rat prostate at aging, related to dyslipidemia and testosterone reduction. The high-lipid nutritional environment from intrauterine and throughout life favors the development of prostatic intraepithelial neoplasia and aggravated degenerative alterations in the gland.

Abstract

Maternal obesity and high-fat diet (HFD) affect permanently prostate histophysiology in adulthood, but the consequences during aging are unknown. Here, we evaluated the prostate alterations in middle-aged rats subjected to a high-lipid nutritional environment (HLE) in different ontogenetic periods. Wistar rats (56 weeks of age) were assigned into groups exposed to standard nutrition (C) or HLE during gestation (G), gestation and lactation (GL), from lactation onward (L), from weaning onward (W) and from gestation onward (AL). HLE in the periods after weaning consisted of HFD (20% fat), and during gestation and lactation it also included previous maternal obesity induced by the HFD. HLE increased total cholesterol and triglyceride levels in all groups and led to insulin resistance in GL and AL and obesity in L. Serum testosterone levels decreased ~67% in GL, ~146% in L and W, and ~233% in AL. Histological and stereological analysis revealed an increment of the stromal compartment and collagen fibers in the prostates of all HLE groups, as well as degenerative lesions, such as cell vacuolation and prostate concretions. HLE aggravated acinar atrophy in G, GL, and L, and in AL it reached more than 50% of the prostate area for most animals. The foci of prostatic intraepithelial neoplasia increased in AL. Tissue expression of androgen receptor did not vary among groups, except for a higher stromal expression for G and GL. Even when restricted to gestation and lactation, HLE induces diffuse acinar atrophy in the aging prostate and worsens degenerative and premalignant lesions when it continues throughout life.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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