Interferon-λ contributes to endometrial receptivity

in Reproduction
Authors:
Kezhen YaoDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China

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https://orcid.org/0000-0003-0240-9056
,
Yu SunDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China

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Xiaoqun YeDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China

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, and
Ying WuThe Swedish University of Agricultural Sciences, Uppsala, Sweden

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Correspondence should be addressed to K Yao; Email: kezhenyao@zju.edu.cn
DOI:
https://doi.org/10.1530/REP-22-0463
Volume/Issue:
Volume 165: Issue 6
Page Range:
569–582
Article Type:
Research Article
Online Publication Date:
21 Apr 2023
Copyright:
© Society for Reproduction and Fertility 2023
Restricted access

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In brief

IFN-λs participate in the fetal–maternal immune interaction, involving in immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. Our study helps to elucidate the underlying causes of the IFN-λs deficiency to spontaneous pregnancy loss in women.

Abstract

Immunotherapy has been commonly used to prevent recurrent pregnancy loss in women with inadequate uterus receptivity or immunological imbalance. Many immune regulators are now identified as having crucial roles at the embryo–maternal interface. However, the clinical efficacy of immunity-related markers during the peri-implantation period remains to be explored in depth. Here, we demonstrated that endometrial expression of interferon-λ (IFN-λ), regarded as a newer class of interferons, is aberrantly lower in women who suffered from recurrent implantation failure than that in fertile control. We further uncovered genetic and biochemical evidence that IFN-λ is induced directly by estrogen in the endometrial cells, and IFN-λ pathway may play multiple roles involving the inflammatory response, uterine receptivity, cell migration, and blastocyst adhesion. Furthermore, we indicated IFN-λ lessens the sensitivity of endometrium to FASL-mediated apoptosis. In addition to uncovering this IFN-λ as a novel nonredundant regulator that participates in the fetal–maternal immune interaction, our study helps to elucidate the underlying causes of spontaneous pregnancy loss in women.

Supplementary Materials

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 82 82 33
PDF Downloads 107 107 46

 

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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