Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?

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Authors:
Chad S Driscoll Department of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA

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Jaehwan Kim Department of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA

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Mohamed Ashry Department of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA

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Jason G Knott Department of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA

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https://orcid.org/0000-0003-1626-7933

Correspondence should be addressed to J G Knott; Email: knottj@msu.edu

*(C S Driscoll and J Kim contributed equally to this work)

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Transcription factor AP2 gamma (TFAP2C) is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here, we hypothesize and provide new evidence that TFAP2C functions as an activator of trophoblast and pluripotency genes during preimplantation embryo development.

 

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