Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation

in Reproduction
Authors:
Niuyi Zheng Department of Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

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https://orcid.org/0000-0001-7025-7977
,
Chaolong Wang Department of Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

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https://orcid.org/0009-0000-8220-1567
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Yiqiu Li Department of Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

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Haiying Fu Department of Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

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, and
Tao Hu Department of Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

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Correspondence should be addressed to T Hu; Email: taohu986@xzhmu.edu.cn

* (N Zheng and C Wang contributed equally to this work)

DOI:
https://doi.org/10.1530/REP-24-0034
Volume/Issue:
Volume 167: Issue 6
Article ID:
e240034
Article Type:
Research Article
Online Publication Date:
02 May 2024
Copyright:
© the author(s) 2024
Restricted access
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In brief

Brown adipose tissue impaired in polycystic ovary syndrome (PCOS) plays a crucial role in the treatment of PCOS. This study shows that myricetin potently improves PCOS by activating brown adipose tissue (BAT).

Abstract

PCOS is a complex endocrine disease characterized by hyperandrogenism, anovulation and polycystic ovary, and is often accompanied by metabolic disorder such as insulin resistance. BAT has been considered as a promising target for the treatment of obesity and other metabolic disease. In this study, we showed that 3 weeks of myricetin (a compound from natural product) treatment improved metabolic capacity and insulin sensitivity by activating BAT in dehydroepiandrosterone (DHEA)-induced PCOS mice. Furthermore, increased number of corpus luteum and decreased cystic formation were observed in PCOS mice. With the hormone levels such as luteinizing hormone (LH) were reversed, estrous cycle was also normalized after myricetin treatment. Eventually, myricetin markedly improved reproductive defects in PCOS mice. In short, our results suggest that myricetin treatment dramatically ameliorates ovarian dysfunction and metabolic disturbances in PCOS and provides a novel perspective for the treatment of PCOS.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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