This paper forms part of a special series on the Impact of Real-Life Environmental Exposures on Reproduction. The Guest Editors for this special series were Professor Jodi Flaws (University of Illinois at Urbana-Champaign, IL, USA) and Professor Vasantha Padmanabhan (University of Michigan, MI, USA).
Author name change: We have not changed the names of the authors since the initial submission.
This review article highlights the associations between endocrine-disrupting chemicals, reproductive aging, and menopause. Collectively, the current literature indicates that phthalates, bisphenols, parabens, per- and poly-fluoroalkyl substances, polychlorinated biphenyls, dioxins, and pesticides are associated with reproductive aging in women and animal models.
Menopause marks the end of a woman’s reproductive lifetime and can have a significant effect on a woman’s quality of life. Menopause naturally occurs at 51 years of age on average, but recent literature suggests that endocrine-disrupting chemicals (EDCs) in our environment can accelerate reproductive aging, causing women to reach menopause at earlier ages. This is concerning as menopause can significantly alter a woman’s quality of life and is associated with increased risks of conditions such as depression, osteoporosis, and cardiovascular disease. EDC exposures have also been associated with more intense menopausal symptoms, making the menopausal transition more difficult for some women. This review highlights the associations between EDC exposure, early menopause, and reproductive aging, using both epidemiological and experimental studies.
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Sept 2018 onwards | Past Year | Past 30 Days | |
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Full Text Views | 79 | 79 | 55 |
PDF Downloads | 115 | 115 | 82 |