Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells

in Reproduction
Authors:
Prianka H Hashim Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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https://orcid.org/0000-0003-2959-8416
,
Madeline J Perry Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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,
Michele T Pritchard Department of Pharmacology, Toxicology and Therapeutics, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA

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Jennifer L Gerton Department of Pharmacology, Toxicology and Therapeutics, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA
Stowers Institute for Medical Research, Kansas City, Missouri, USA

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, and
Francesca E Duncan Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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https://orcid.org/0000-0002-3756-9394

Correspondence should be addressed to F E Duncan: f-duncan@northwestern.edu
DOI:
https://doi.org/10.1530/REP-25-0042
Volume/Issue:
Volume 169: Issue 5
Article ID:
e250042
Article Type:
Review Article
Online Publication Date:
01 Apr 2025
Copyright:
© the author(s) 2025
Restricted access
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We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 82 82 48
PDF Downloads 114 114 63

 

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Print ISSN:
1470-1626
Online ISSN:
1741-7899

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