The activity pattern and functional significance of leucine aminopeptidase (LAP) have been studied in the testes of oestrogen-treated, cryptorchid and HCG-treated guinea-pigs. The enzyme was present only in the Leydig cells and showed marked fluctuations in its activity pattern, which correlated closely with alterations in the functional activities of the Leydig cells. Hyperfunctioning Leydig cells exhibited enhanced LAP activity, whereas hypofunctioning of these intertubular cells resulted in a diminution in the enzyme activity. The LAP activity in the intertubular Leydig cells may be regarded as a cytochemical marker enzyme in the assessment of Leydig cell function in the guinea-pig testes under varying experimental conditions.
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