COMPENSATORY OVULATION IN BLINDED RATS AND/OR THOSE FROM WHICH THE OLFACTORY BULB HAD BEEN REMOVED

in Reproduction

Summary.

Thirty-two prepubertal, female rats (Southern Farms) were allocated to intact control, bilateral optic enucleation (blinded), bilateral olfactory bulb removal (anosmic) and blinded—anosmic groups. Olfactory bulbs were surgically removed between 27 and 29 days of age and eyes were removed at 30 days of age. One ovary was removed from each animal between 107 and 112 days of age on Day 2 (metoestrus) of the oestrous cycle. The number of eggs ovulated was determined by flushing the oviducts with normal saline solution. All rats completed one oestrous cycle and were killed at metoestrus of the following cycle. There was no difference in the number of ova shed between the four groups at the time of removal of the first ovary. One cycle later, compensatory ovulation was found at autopsy to have occurred in all animals. Controls ovulated 10·3±0·5 eggs; blinded, 9·6±0·7; anosmic, 10·3±0·3; and blinded—anosmic, 9·7±0·8. Follicular development was quantitatively analysed in both intact and hemispayed blinded and/or anosmic rats. These data suggest that pituitary—ovarian function as evaluated by the number of eggs ovulated is not affected by blinding and/or anosmia.

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    Society for Reproduction and Fertility

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