Androgens are capable of maintaining the progressive development of the germ cells in immature male rats which have either been hypophysectomized (Leathem, 1944; Ludwig, 1950; Lostroh, 1969) or treated with compounds which interfere with the release and/or secretion of gonadotrophins (Ludwig, 1950; Kalra & Prasad, 1967; Steinberger & Steinberger, 1969). Similar results have also been obtained in adult male rats (Boccabella, 1963; Clermont & Harvey, 1967; Lacy & his co-authors, 1969). Studies on steroid metabolism in vitro by isolated seminiferous tubules of rats denuded of their germ cells by heat-treatment has led to the view that not only Leydig cells but also Sertoli cells may be a major source of androgens (Collins, Bell & Vinson, 1968; Lacy et al., 1969). Similar conclusions have also been reached by Ellis & van Kampen (1971) from studies on
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