EFFECT OF (+)-INPEA ON CONTRACTIONS OF THE ISOLATED RAT UTERUS EVOKED BY PROSTAGLANDINS

in Reproduction

Summary.

The effect of oral (100 mg/kg) and intraperitoneal (10 mg/kg) administration of (+)-INPEA on contractions of the isolated rat uterus evoked by PGE1, PGE2 and PGF has been investigated. Administration of (+)-INPEA by both routes increased the sensitivity of the uterus to each of the prostaglandins studied. Since (+)-INPEA appears to be non-toxic, its potentiating action may enable clinicians to use smaller doses of prostaglandins for therapeutic abortion or for the induction of labour.

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    Society for Reproduction and Fertility

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