INFLUENCE OF THE TRIPEPTIDE, PRO-ARG-GLY-(NH2), ON OVULATION INDUCED WITH LH OR SYNTHETIC LH-FSH RELEASING HORMONE IN CHLORPROMAZINE-TREATED PRO-OESTROUS RATS

in Reproduction

Vasopressin increases the ovulatory response to PMSG in immature rats (de la Lastra & Forcelledo, 1970). This effect of vasopressin on ovulation, as well as the similarity between the three terminal amino acids of arginine-vasopressin (AVP) and LH-FSH releasing hormone (LH-FSH-RH), induced us to study the influence of the peptide, Pro-Arg-Gly-NH2 (PAGA), which is the terminal fragment of AVP, on the ovulation induced in adult rats with LH or LH-FSH-RH.

Both LH-FSH-RH and PAGA were synthesized by the solid-phase method, using standard techniques (Stewart & Young, 1969). The normal chloromethylated 1% cross-linked polystyrene was used as support, and α-amino groups were blocked with the tert-butyloxycarbonyl group. Toluenesulphonyl blocking groups were used for histidine- and arginine-side

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    Society for Reproduction and Fertility

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