It Takes Two (Centrioles) to Tango

in Reproduction
Correspondence: Tomer Avidor-Reiss, Email: Tomer.AvidorReiss@utoledo.edu
Restricted access

Abstract

Cells that divide during embryo development require precisely two centrioles during interphase and four centrioles during mitosis. This precise number is maintained by allowing each centriole to nucleate only one centriole per cell cycle (i.e. centriole duplication). Yet, how the first cell of the embryo, the zygote, obtains two centrioles has remained a mystery in most mammals and insects. The mystery arose because the female gamete (oocyte) is thought to have no functional centrioles and the male gamete (spermatozoon) is thought to have only one functional centriole, resulting in a zygote with a single centriole. However, recent studies in fruit flies, beetles, and mammals, including humans, suggest an alternative explanation: spermatozoa have a typical centriole and an atypical centriole. The typical centriole has a normal structure but distinct protein composition, whereas the atypical centriole is distinct in both. During fertilization, the atypical centriole is released into the zygote, nucleates a new centriole, and participates in spindle pole formation. Thus, the spermatozoa’s atypical centriole acts as a second centriole in the zygote. Here, we review centriole biology in general and especially in reproduction, we describe the discovery of the spermatozoon atypical centriole, and we provide an updated model for centriole inherence during sexual reproduction. While we focus on humans and other non-rodent mammals, we also provide a broader evolutionary perspective.

 

An official journal of

Society for Reproduction and Fertility

Index Card

PubMed

Google Scholar

Related Articles

Altmetrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 78 78 78
Full Text Views 90 90 90
PDF Downloads 91 91 91