Bioactive fragments of laminin and collagen chains – Lesson from the testis

in Reproduction
Correspondence: C Yan Cheng, Email: Y-Cheng@popcbr.rockefeller.edu
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Recent studies have shown that the testis is producing several biologically active peptides, namely the F5- and the NC1-peptides from laminin-γ3 and collagen α3 (IV) chain, respectively, that promotes blood-testis barrier (BTB) remodeling and also elongated spermatid release at spermiation. Also the LG3/4/5-peptide from laminin-α2 chain also promotes BTB integrity which is likely being used for the assembly of a “new” BTB behind preleptotene spermatocytes under transport at the immunological barrier. These findings thus provides a new opportunity for investigators to better understand the biology of spermatogenesis. Herein, we briefly summarize these recent findings and provide a critique update and a hypothetical model which can serve as the framework for studies in the years to come.

 

    Society for Reproduction and Fertility

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