Polycystic Ovary Syndrome: Origins and Implications

 

Reproduction has a growing collection of reviews and research articles focused on Polycystic ovary syndrome (PCOS).

Polycystic ovary syndrome (PCOS) is a common reproductive-metabolic syndrome of ovarian hyperandrogenism linked with insulin resistance and preferential abdominal fat accumulation worsened by obesity. In today’s obesogenic environment, the complex interplay between hyperandrogenism and insulin resistance in women with PCOS increases their susceptibility to several reproductive and metabolic diseases, including anovulatory infertility, diabetes and metabolic syndrome/or cardiovascular disease. 

This collection addresses several important topics relevant to PCOS, including epidemiological and genetic aspects, evolutionary origins, androgenic-metabolic implications, pregnancy outcomes, animal models, adolescent development and long-term health.

This special collection is edited by the guest editors, Professor Daniel A. Dumesic, University of California Los Angeles, USA, Professor David H. Abbott, University of Wisconsin and Wisconsin National Primate Research Center, USA, and our Reviews Editor, Professor Vasantha Padmanabhan, University of Michigan, USA.

 

 

Consider submitting relevant articles for publication in the journal. Visit our author guidelines, to find out more about the submission process.

 

Read the latest articles published in this special collection:

 

POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Polycystic ovary syndrome: an evolutionary metabolic adaptation
Daniel A Dumesic, Vasantha Padmanabhan, and David H Abbott

 

Collection Editors

Photo of Professor Daniel A. Dumesic

Professor Daniel A. Dumesic, Guest Editor

Division of Reproductive Endocrinology and Infertility, 
Department of Obstetrics and Gynecology, 
University of California Los Angeles, CA, USA

Daniel Dumesic, MD is Professor of Reproductive Endocrinology and Infertility at the
University of California, Los Angeles. His clinical and research interests include female
infertility, in vitro fertilization and polycystic ovary syndrome (PCOS). Dr. Dumesic has received
innumerable awards, including the Mayo Award for Excellence in Leadership, and is an eleven-time
recipient of the “Star Award” from the American Society for Reproductive Medicine. He has
published over 200 papers in the field of reproductive endocrinology and has received the
Ricardo Azziz Distinguished Researcher Award from the AE-PCOS Society.

Photo of Professor David H. Abbott

Professor David H. Abbott, Guest Editor

Department of Obstetrics and Gynecology, 
University of Wisconsin 
and Wisconsin National Primate Research Center, 
Madison, WI, USA

Professor David Abbott is a Senior Scientist at the Wisconsin National Primate Research Center.  He is a
past-president of the Androgen Excess and PCOS Society and a recipient of their Ricardo Azziz Distinguished
Researcher Award. He utilizes nonhuman primate models of female reproductive endocrinology to determine
molecular mechanisms underlying the pathogenesis of polycystic ovary syndrome (PCOS), including the
genetic and developmental origins of naturally occurring hyperandrogenism in female monkeys with PCOS-like phenotypes.
Picture of Professor Vasantha Padmanabhan

Professor Vasantha Padmanabhan, Reviews Editor    

Department of Pediatrics, 
University of Michigan, Ann Arbor, MI, USA

Vasantha Padmanabhan M.S., Ph.D. is Professor Emerita (In service) of Pediatrics, Obstetrics, and Gynecology, Molecular and Integrative Physiology, Environmental Health Sciences, and
Nutritional Sciences, University of Michigan, MI, USA. Her research centers on delineating the developmental origin of reproductive and metabolic disorders such as that seen in hyperandrogenic disorders like polycystic ovarian syndrome (PCOS) and identifying prevention and treatment strategies. ​With over 200 publications to her credit, she is the recipient of 2022 Ricardo Azziz Distinguished Researcher Award from the AE-PCOS Society. She was recently named 2024 Society for Study of Reproduction Distinguished Fellow.