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Alessandra Santillo, Massimo Venditti, Sergio Minucci, Gabriella Chieffi Baccari, Sara Falvo, Luigi Rosati, and Maria Maddalena Di Fiore

, Burrone et al. 2010 , Santillo et al. 2014 , 2018 ). Specifically, D-Asp has been found to be located in Leydig cells (LC), Sertoli cells (SC), as well as in germ cells (GC), notably in spermatogonia (SPG), elongate spermatids (SPT) ( Tomita et al

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Zhi-hui Cui, Yong-dan Ma, Yi-cheng Wang, Huan Liu, Jia-wei Song, Li-xue Zhang, Wen-jing Guo, Xue-qin Zhang, Sha-sha Tu, Dong-zhi Yuan, Jin-hu Zhang, Li Nie, and Li-min Yue

cytoplasm of Leydig cells in the form of cholesterol esters where testosterone is primarily produced ( Martin & Parton 2006 ). Lacking serum testosterone levels is usually associated with primary or delayed hypogonadism and decreased reproductive capacity

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Frank Pfennig, Thomas Kurth, Stefan Meißner, Andrea Standke, Markus Hoppe, Freia Zieschang, Christine Reitmayer, Andy Göbel, Georg Kretzschmar, and Herwig O Gutzeit

compartment or interstitium and is filled with steroidogenic Leydig cells (LC), blood vessels, macrophages, mast cells, neuronal cells and connective tissue cells (reviewed in Schulz et al . (2010) ). The testis is enclosed by an epithelium with a thin

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Juho-Antti Mäkelä, Vuokko Saario, Sonia Bourguiba-Hachemi, Mirja Nurmio, Kirsi Jahnukainen, Martti Parvinen, and Jorma Toppari

seminiferous epithelium, disrupted spermatogenesis may partly be due to low androgen levels since Hh signalling is needed for the differentiation of foetal Leydig cells ( Yao et al . 2002 , Barsoum et al . 2009 ) and to maintain the expression of

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Meenakshi Gaur, Cyril Ramathal, Renee A Reijo Pera, Paul J Turek, and Constance M John

describe a protocol for the isolation of cell populations enriched for three major human testicular somatic cells, Leydig cells (LCs), peritubular myoid cells (PCs) and Sertoli cells (SCs) from testes of a single human donor. Previous studies have shown

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Katrine Harpelunde Poulsen and Anne Jørgensen

cords, dividing the gonads into two compartments – the seminiferous cords containing the Sertoli cells and germ cells, and the interstitial space consisting of fetal Leydig cells, progenitors of adult Leydig cells and peritubular myeloid cells ( Wilhelm

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Franca Raucci and Maria Maddalena Di Fiore

. 1991 , Manova et al. 1993 , Vincent et al. 1998 , Sette et al. 2000 ) and Leydig cells ( Manova et al. 1990 , Motro et al. 1991 , Rossi et al. 1991 ). For its exclusive expression, c-kit receptor could be used as a specific marker for

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Francisco Jiménez-Trejo, Miguel Tapia-Rodríguez, Marco Cerbón, Donald M Kuhn, Gabriel Manjarrez-Gutiérrez, C Adriana Mendoza-Rodríguez, and Ofir Picazo

. 1996 ), testicular growth, cAMP production, and testosterone production ( Tinajero et al . 1993 , Frungieri et al . 2002 ). Additionally, the LH induces 5-HT release from Leydig cells via a cAMP-dependent pathway, which promotes the secretion of

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Li Chen, Jiajia Bi, Masaaki Nakai, David Bunick, John F Couse, Kenneth S Korach, and Romana A Nowak

Epithelial cells ++ ++ ++ Uterus Epithelial cells ++ (proest, est) − ++ (proest, est) Stroma cells − − − Testis Sertoli cells ± ± ± Leydig cells ++ ++ ++ Spermatogonia − − − Spermatocytes ++ ++ ++ Spermatid ++ ++ ++ Sperm ++ ++ ++ Efferent ductule Ciliated

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A. E. Drummond, G. P. Risbridger, P. C. O'Leary, and D. M. de Kretser

Summary. A single dose of EDS was given to mature male rats and interstitial fluid (IF) was collected to determine the potency of mitogenic and steroidogenic activities therein. The potency of the factor stimulating testosterone secretion in vitro by Percoll-purified Leydig cells was significantly elevated 2 weeks after EDS, whilst the potency of mitogenic activities (stimulation of DNA synthesis by BALB/c 3T3 cells) was not elevated until 4 weeks after EDS treatment.

This study suggests that two separate factors, one with mitogenic and the other steroidogenic activity, may be involved in the response of Leydig cells after EDS administration. The mitogenic factor may play a role in Leydig cell regeneration whereas the testosterone-stimulating factor may be involved in testicular testosterone homeostasis.

Keywords: mitogenesis; interstitial fluid; steroidogenesis; Leydig cell