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Séverine Mazaud Guittot, Adélie Vérot, Fanny Odet, Marie-Agnès Chauvin, and Brigitte le Magueresse-Battistoni

that contains the steroidogenic Leydig cells. In the testis, the biological functions and composition of the BM surrounding the seminiferous tubules have been the subject of many investigations, and its importance is highlighted with the finding that

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Yasuhiro Kawai, Junko Noguchi, Kouyou Akiyama, Yuriko Takeno, Yasuhiro Fujiwara, Shimpei Kajita, Takehito Tsuji, Kazuhiro Kikuchi, Hiroyuki Kaneko, and Tetsuo Kunieda

of the peritubular myoid cells, which also contribute to formation of testicular cords ( Martineau et al . 1997 , Capel et al . 1999 , Tilmann & Capel 1999 ). Thereafter, steroidogenic Leydig cells appear in the extra-cordal region of the male

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Xiaoheng Li, Lanlan Chen, Yiyan Wang, Huitao Li, Qiqi Zhu, and Ren-Shan Ge

Introduction Testosterone secreted by Leydig cells (LCs) is pivotal for maintaining secondary sexual characteristics, promoting spermatogenesis, and enhancing sexual libido and muscle strength of adult males ( Chen et al. 2020 ). LCs

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Francis Bergeron, Gabriel Nadeau, and Robert S Viger

associated with the knockouts. In comparison to Sertoli cells of the testis, conditional Gata4 knockout models have been less useful for studying steroidogenic (Leydig) cells, as reliable Leydig cell-specific Cre drivers, especially in the adult, are

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María E Matzkin, Silvia I Gonzalez-Calvar, Artur Mayerhofer, Ricardo S Calandra, and Mónica B Frungieri

context, we have reported that although PTGS2 is not detected in normal human testes, it is expressed in interstitial cells, presumably Leydig cells, in testicular biopsies of men with impaired spermatogenesis and male infertility ( Frungieri et al . 2002

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Meng-Chieh Hsu, Leang-Shin Wu, De-Shien Jong, and Chih-Hsien Chiu

Leydig cell ( Salehi et al . 2015 ). However, the intracellular signaling pathway in LH-induced Kiss1 expression has not yet been well described. In the Leydig cell, the primarily downstream signal transduction pathway of luteinizing hormone

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Mickaël Di-Luoffo, Kenley Joule Pierre, Nicholas M Robert, Marie-Joëlle Girard, and Jacques J Tremblay

Introduction The small peptide hormone insulin-like 3 (INSL3) is produced almost exclusively by Leydig cells within the male gonads. During fetal life, INSL3 is essential for the transabdominal phase of testicular descent ( Nef & Parada 1999

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P J O'Shaughnessy, L Hu, and P J Baker

different mRNA species expressed specifically in the Sertoli cells as germ cell depletion progresses. Androgen secretion by the testis is dependent upon the Leydig cells, which are regulated by luteinising hormone (LH). There is also good evidence, however

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Six normal men were injected with 4000 i.u. of hcg intramuscularly three times a week for 6 weeks or every 2nd day for 16 weeks. Levels of urinary testosterone and oestrogens were measured. Leydig cells were quantified on the basis of the Leydig cell/Sertoli cell ratio, and Leydig-cell size was measured.

Following both 6 and 16 weeks hcg administration, four subjects showed no change in Leydig-cell numbers. The remaining subjects showed slight increases or decreases. Levels of urinary testosterone and oestrogen increased. It is concluded that there is no consistent increase in Leydig-cell numbers following hcg administration. Measurements of Leydig-cell nucleus and cytoplasm revealed a significant increase in the size of both at 6 and 16 weeks in all but one subject. It is concluded that the increased activity of the Leydig cells is related to their increase in size and not to an increase in number as had been reported.

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S M L C Mendis-Handagama, H B S Ariyaratne, L Mrkonjich, and R Ivell

Introduction The peptide hormone insulin-like peptide 3 (INSL3), previously referred to as relaxin-like factor, or Leydig cell-derived insulin-like factor, is regarded as a marker for Leydig cells of the postpubertal testis in many