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Neil A Youngson, G Mezbah Uddin, Abhirup Das, Carl Martinez, Haley S Connaughton, Sara Whiting, Josephine Yu, David A Sinclair, R John Aitken, and Margaret J Morris

. 1996 , Chavarro et al. 2010 ) and an increase in the localised and systemic levels of oxidative stress ( Gavriliouk & Aitken 2015 , Liu & Ding 2017 ). Excess fat deposits have been shown to increase scrotal temperature in humans, which is thought to

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Oriana Bonanno, Giulietta Romeo, Paola Asero, Franca Maria Pezzino, Roberto Castiglione, Nunziatina Burrello, Giuseppe Sidoti, Giovanni Vanni Frajese, Enzo Vicari, and Rosario D’Agata

quantitative alterations in abnormal sperm may be because of impaired mitochondrial maintenance or oxidative stress-induced deleterious effects on mtDNA ( May-Panloup et al. 2003 , Shamsi et al . 2009 , Venkatesh et al. 2009 ). Since nuclear and

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Róisín A Griffin, Mark Baker, Robert John Aitken, Aleona Swegen, and Zamira Gibb

increases the likelihood of embryo loss or birth defects in the offspring ( Aitken et al. 2010 b , Chandra et al. 2012 ). Oxidative stress is characterised as a state in which the rate of ROS generation exceeds the rate of its degradation within cells

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Kun Lei, Quanwei Wei, Ying Cheng, Zhe Wang, Haoze Wu, Fang Zhao, Wei Ding, and Fangxiong Shi

apoptosis is thought to be a potential mechanism of follicular atresia ( Hakuno et al. 1996 , Liu et al. 2020 ). Moreover, oxidative stress is considered to be one of the causes of GC apoptosis, particularly in aging, or certain pathological conditions

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Alexandra Dăneasă, Cristina Cucolaş, Lavinia Manuela Lenghel, Diana Olteanu, Remus Orăsan, and Gabriela A Filip

( Karakas et al . 2010 ). Moreover, oxidative stress ( Sabuncu et al . 2001 ) and low-grade inflammation ( Duleba & Dokras 2012 ) are emerging as factors in the pathogenesis of the syndrome. Women with PCOS have an increased oxidative status which is

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J Vanderlelie, K Venardos, and A V Perkins

prevalence and severity the pathophysiology of this multi-system disorder is still poorly understood. Placental oxidative stress has been shown to be a key feature in the pathogenesis of PET (for reviews see Walsh 1998 , Hubel 1999 , Redman & Sargent 2000

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Catherine M H Combelles, Emily A Holick, Louis J Paolella, David C Walker, and Qiaqia Wu

, oxidative stress (OS) may ensue. OS refers to an imbalance between the concentrations of pro- and antioxidants, thereby resulting in compromised cellular functions; sources of pro-oxidants are extensive, including their generation as byproducts of cellular

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Dominika Celar Sturm and Irma Virant-Klun

reproductive system largely through binding to estrogen receptors (ERs) and thus stimulating estrogen function or via oxidative stress-related damage ( Tsutsumi 2005 ). BPA can affect ovarian function, especially steroidogenesis and follicular growth, and even

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José A Pino, Nelson Osses, Daniela Oyarzún, Jorge G Farías, Ricardo D Moreno, and Juan G Reyes

Introduction The increase in testicular temperature observed in cryptorchidia and varicocele has been associated with an increase in testicular oxidative stress ( Peltola et al . 1995 ). Reactive oxygen species/reactive nitrogen species (ROS

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M Plaza Davila, P Martin Muñoz, J M Gallardo Bolaños, T A E Stout, B M Gadella, J A Tapia, C Balao da Silva, C Ortega Ferrusola, and F J Peña

addition, we studied the role of glycolysis using 2-deoxyglucose (2-DG). As mitochondrial dysfunction can also lead to oxidative stress, we simultaneously monitored the production of reactive oxygen species. Our results suggest that, in contrast to many