, containing Leydig cells, macrophages, connective tissue, and vasculature. The development of the testicular vasculature and seminiferous cords is simultaneous, promoted by VEGF secreted by macrophages, and PDGF from somatic cells at the testis
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Badia Barakat, Anne E O'Connor, Elspeth Gold, David M de Kretser, and Kate L Loveland
( Vergouwen et al . 1991 ). Leydig cells differentiate from fetal Leydig cells to adult Leydig cells at around 7 dpp ( Vergouwen et al . 1993 ) and do not start to proliferate until after 21 dpp to reach adult levels by 35 dpp ( Vergouwen et al . 1991
Amanda V Albuquerque, Fernanda R C L Almeida, Connie C Weng, Gunapala Shetty, Marvin L Meistrich, and Hélio Chiarini-Garcia
total length) containing flutamide (Sigma–Aldrich; Porter et al . 2009, Zhou et al . 2010 ). Additionally, to evaluate the effects of absence and Leydig cell factors, the Leydig cells were destroyed after a single i.p. dose (75 mg/kg) of ethane
S Goericke-Pesch, M Gentil, A Spang, M P Kowalewski, K Failing, and B Hoffmann
spermatogonia only or spermatogonia and primary spermatocytes and the respective percentage was calculated. Area of Leydig cell nuclei was determined as described earlier ( Goericke-Pesch et al . 2009 ). Slides stained for AR and evaluated as described below
Rajani M George, Katherine L Hahn, Alan Rawls, Robert S Viger, and Jeanne Wilson-Rawls
in Leydig cells. FSH also regulates the number of Sertoli and Leydig cells ( Baker & O'Shaughnessy 2001 , Baker et al . 2003 ). During folliculogenesis, granulosa cells respond differently to FSH depending on follicle size. In small preantral
Sarah J Potter and Tony DeFalco
peritubular populations of cells that influence SSC behavior. The mammalian testicular interstitium contains vasculature, Leydig cells, and macrophages, while the peritubular region consists of peritubular myoid cells (PMCs) and macrophages ( Fig. 2 ). All of
Paulo Henrique Almeida Campos-Junior, Guilherme Mattos Jardim Costa, Gleide Fernandes Avelar, Samyra Maria Santos Nassif Lacerda, Nathália Nogueira da Costa, Otávio Mitio Ohashi, Moysés dos Santos Miranda, Lucíola Silva Barcelos, Érika Cristina Jorge, Diva Anelie Guimarães, and Luiz Renato de França
Leydig cells are observed almost exclusively surrounding the seminiferous tubule lobes ( Costa et al . 2010 , Campos-Junior et al . 2012 ). Taking advantage of this peculiar feature, we found that, different from what is suggested in the literature
Tomoko Kato, Michiyo Esaki, Ayami Matsuzawa, and Yayoi Ikeda
sex differentiation ( Shen et al . 1994 , De Santa Barbara et al . 1998 , Nachtigal et al . 1998 , Arango et al . 1999 , Watanabe et al . 2000 ). In Leydig cells, NR5A1 controls the expression of steroid biosynthetic enzyme genes including
Olga M Ocón-Grove, Susan M Krzysik-Walker, Sreenivasa R Maddineni, Gilbert L Hendricks III, and Ramesh Ramachandran
data indicate that NAMPT expression within the testis undergoes a dramatic shift from nuclear localization in myoid cells and Leydig cells in prepubertal chickens to cytoplasmic localization in primary spermatocytes, Sertoli cells, Leydig cells, and
Olga M Ocón-Grove, Susan M Krzysik-Walker, Sreenivasa R Maddineni, Gilbert L Hendricks III, and Ramesh Ramachandran
cells ( Fig. 2 A, D, G, H, and K). Diffuse adiponectin immunostaining was also noticed throughout the interstitium ( Fig. 2 K) as well as in the cytoplasm of Leydig cells ( Fig. 2 H and K). Based on the flattened morphology of cells in the peritubular
