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M Ethier-Chiasson, J-C Forest, Y Giguère, A Masse, C Marseille-Tremblay, E Lévy, and J Lafond

, the maternal lipoprotein profiles are greatly modified ( Herrera 2002 ). Fundamentally, pregnancy is associated with an oxidative stress state arising from the increasing metabolic activity of placental mitochondria and the decreasing scavenging by

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María Guillermina Bilbao, María Paula Di Yorio, Rocío Alejandra Galarza, Cecilia Laura Varone, and Alicia Graciela Faletti

oxygen species (ROS; Agarwal et al . 2012 , Rizzo et al . 2012 ). Although oxidative stress may be a physiological state in certain conditions, it may increase when the production of ROS exceeds or saturates the antioxidant levels. ROS are of

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Arvinder Kapur, Jose M Ayuso, Shujah Rehman, Santosh Kumari, Mildred Felder, Zach Stenerson, Melisa C Skala, Dave Beebe, Lisa Barroilhet, and Manish S Patankar

approach to controlling endometriosis. In our prior work in ovarian cancer models, we demonstrated that agents such as plumbagin, atovaquone, and curcumin (Kapur and Patankar et al , unpublished reports) induce oxidative stress and thereby induce apoptosis

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Fritzie T Celino, Sonoko Yamaguchi, Chiemi Miura, and Takeshi Miura

observed. (D) 100 μM arsenic with hCG-treated group. Note the increase in number of germ cells with positive-TUNEL labeling. Bars, 20 μm. Induction of oxidative stress by arsenic When cells are attacked by reactive oxygen species (ROS), DNA is oxidized, and

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Cansu Agca, James E Ries, Sarah J Kolath, Jae-Hwan Kim, Lawrence J Forrester, Eric Antoniou, Kristin M Whitworth, Nagappan Mathialagan, Gordon K Springer, Randall S Prather, and Matthew C Lucy

-binding proteins; metabolic enzymes, mitochondrial transporters, and proteins involved in the oxidative stress response; ligands, receptors, and receptor pathways (predominantly the cAMP response system); and cell proliferation/differentiation. For genes whose

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Mazdak Salavati, Fataneh Ghafari, Tiantian Zhang, and Ali A Fouladi-Nashta

droplets in ooplasm has an impeccable influence on predisposition of cumulus oocyte complexes (COCs) to oxidative stress by reactive oxygen species (ROS; Wakefield et al . 2008 , Whitaker & Knight 2008 , Tao et al . 2010 ). Oxygen concentration during

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Felipe Martínez-Pastor, Eduardo Aisen, María Rocío Fernández-Santos, Milagros C Esteso, Alejandro Maroto-Morales, Olga García-Álvarez, and J Julián Garde

Introduction Oxidative stress has emerged as one of the major threats to sperm functionality, both in vivo and in vitro . Reactive oxygen species (ROS) have a fundamental role in sperm physiology ( Aitken et al . 2004 , O'Flaherty et al . 2006

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Daniela F da Silva, Thaís A Rodrigues, Juliano C da Silveira, Angela M Gonella-Diaza, Mario Binelli, Juliana V Lopes, Marcelo T Moura, Weber B Feitosa, and Fabíola F Paula-Lopes

, Meistrich et al . 2003 , Johnson et al . 2011 ). Such unique chromatin architecture suggests that mature sperm has a reduced ability to respond to environmental insults such as elevated temperature, cryopreservation, and oxidative stress ( González

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R S Tavares, S Escada-Rebelo, M Correia, P C Mota, and J Ramalho-Santos

) PCBs  Aroclor 1254 Rat 10 −9 , 10 −8 , and 10 −7  M (6) Aly (2013) BPA  BPA Mouse 0.0001, 0.01, 1, and 100 μM (4) Rahman et al . (2015) Oxidative stress Pesticides  Alachlor Human 0

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Thais Rose dos Santos Hamilton, Letícia Signori de Castro, Juliana de Carvalho Delgado, Patrícia Monken de Assis, Adriano Felipe Perez Siqueira, Camilla Mota Mendes, Marcelo Demarchi Goissis, Teresa Muiño-Blanco, José Álvaro Cebrián-Pérez, Marcílio Nichi, José Antonio Visintin, and Mayra Elena Ortiz D'Ávila Assumpção

(ROS) are generated by sperm metabolism. Accumulation of ROS can cause an imbalance in relation to the activity of antioxidant molecules, leading to oxidative stress (OS), which is extremely damaging to all sperm components. Maintaining a balance