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Marie Lindhardt Johansen, Ravinder Anand-Ivell, Annette Mouritsen, Casper P Hagen, Mikkel G Mieritz, Tue Søeborg, Trine Holm Johannsen, Katharina M Main, Anna-Maria Andersson, Richard Ivell, and Anders Juul

Introduction Insulin-like factor 3 (INSL3) is a peptide hormone secreted by Leydig cells in the testis and by theca cells in the ovary. INSL3 exerts its effect through the G-protein-coupled relaxin family peptide receptor 2 (RXFP2) ( Huang et al

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Massimiliano Monticone, Laura Tonachini, Sara Tavella, Paolo Degan, Roberta Biticchi, Fioretta Palombi, Rossella Puglisi, Carla Boitani, Ranieri Cancedda, and Patrizio Castagnola

were found at low level in middle-late pachytene spermatocytes and at higher level in round spermatids and in a sample of interstitial tissue enriched in Leydig cells (Fig. 7 ). Sertoli cells (Fig. 7 ) and spermatogonia (not shown) did not express

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Olivia E Smith, Fanny Morin, Vickie Roussel, Micka C Bertucci, Alexandre Boyer, and Bruce D Murphy

and a combination of both, for the study of this transcription factor specifically in the Leydig cells and Sertoli cells of the testis and in the theca cells and granulosa cells of the ovary. We demonstrate that SF-1 is required for steroidogenesis in

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Mónica B Frungieri, Ricardo S Calandra, Artur Mayerhofer, and María E Matzkin

synthase participates in the SOX9 nuclear translocation necessary for the process of Sertoli cell differentiation ( Rossitto et al . 2015 ). PG receptors have been described in Leydig cells (i.e., EP1, DP, FP, TP, and PPARγ receptors; Walch et al . 2003

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Yue Zhao, Haoran Liu, Yang Yang, Wenqian Huang, and Lan Chao

. The Leydig cells of the testis distributed between the seminiferous tubules are the main field of sex hormone synthesis in males and more than 95% of testosterone is synthesized and secreted by this cell ( Tremblay 2015 ). Testosterone is the body

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Shi-Yu An, Zi-Fei Liu, El-Samahy M A, Ming-Tian Deng, Xiao-Xiao Gao, Ya-Xu Liang, Chen-Bo Shi, Zhi-Hai Lei, Feng Wang, and Guo-Min Zhang

Introduction Leydig cells (LCs), located in the interstitial tissue of the testis, as the main site of androgen (mainly testosterone (T)) synthesis and secretion, play pivotal roles in regulating secondary male-specific sexual maturation and

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Hyun-Wook Lee, Jill W Verlander, Mary E Handlogten, Ki-Hwan Han, Paul S Cooke, and I David Weiner

was detected only in interstitial cells and not in the seminiferous tubules ( Fig. 3 A and B). High-power micrographs suggested that the interstitial cells with RHBG immunolabel had a location and morphology suggestive of Leydig cells. Figure 3 RHBG

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Nathalie Josso

virilization . Sexual Development 3 . ( ) Racine C Rey R Forest MG Louis F Ferre A Huhtaniemi I Josso N di Clemente N 1998 Receptors for anti-Mullerian hormone on Leydig cells are responsible for its effects on

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Nathália L M Lara and Luiz R França

.6 a 11.2 ± 1.5 b 9.0 ± 1.5 ab  Intertubular compartment 5.5 ± 0.3 5.3 ±0.3 4.3 ± 0.4 4.9 ± 0.4   Leydig cell 3.2 ± 0.2 a 3.1 ± 0.3 a 2.0 ± 0.2 b 2.2 ± 0.2 b   Blood vessels 1.6 ± 0.1 1.3 ± 0.1 1.9 ± 0.2 1

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Yu-Qian Wang, Aalia Batool, Su-Ren Chen, and Yi-Xun Liu

development, spermatogenesis requires significant contributions of somatic cell populations, including testicular Sertoli cells, Leydig cells, peritubular myoid (PTM) cells, blood vessels and macrophages ( Rebourcet et al. 2014 , DeFalco et al. 2015