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P J O'Shaughnessy, L Hu, and P J Baker

different mRNA species expressed specifically in the Sertoli cells as germ cell depletion progresses. Androgen secretion by the testis is dependent upon the Leydig cells, which are regulated by luteinising hormone (LH). There is also good evidence, however

Open access

P J O'Shaughnessy, A Monteiro, G Verhoeven, K De Gendt, and M H Abel

effects of FSH from those of androgen. In early studies, the FSH preparations used contained low levels of LH, which could induce androgen production by the Leydig cells. Use of recombinant FSH has overcome this problem but there remains the issue that FSH

Open access

Juho-Antti Mäkelä, Vuokko Saario, Sonia Bourguiba-Hachemi, Mirja Nurmio, Kirsi Jahnukainen, Martti Parvinen, and Jorma Toppari

seminiferous epithelium, disrupted spermatogenesis may partly be due to low androgen levels since Hh signalling is needed for the differentiation of foetal Leydig cells ( Yao et al . 2002 , Barsoum et al . 2009 ) and to maintain the expression of

Open access

René Habert, Vincent Muczynski, Tiphany Grisin, Delphine Moison, Sébastien Messiaen, René Frydman, Alexandra Benachi, Géraldine Delbes, Romain Lambrot, Abdelali Lehraiki, Thierry N'Tumba-Byn, Marie-Justine Guerquin, Christine Levacher, Virginie Rouiller-Fabre, and Gabriel Livera

adult spermatogonial stem cells during neonatal life, correct development of the germ cell lineage during fetal/embryonic life is essential for the production of spermatozoa during adult life. Fetal Leydig cells differentiate soon after Sertoli cells and

Open access

Caroline M Allen, Federica Lopes, Rod T Mitchell, and Norah Spears

unknown nature of Leydig cell development during this timeframe. (B) Comparison of the histology of the testis throughout development in the human, from foetal development through to the adult testis. dpc, days post coitum; GW, gestational week; pnd

Open access

Richard G Lea, Beatrice Mandon-Pépin, Benoit Loup, Elodie Poumerol, Luc Jouneau, Biola F Egbowon, Adelle Bowden, Corinne Cotinot, Laura Purdie, Zulin Zhang, Paul A Fowler, and Kevin D Sinclair

has been linked to an increased chemical burden in maternal livers and developmental effects in the mid-gestation male fetal testis. These include reduced numbers of gonocytes, Sertoli and Leydig cells, and a parallel reduction in fetal inhibin A and

Open access

Nick Warr, Pam Siggers, Joel May, Nicolas Chalon, Madeleine Pope, Sara Wells, Marie-Christine Chaboissier, and Andy Greenfield

Gadd45g −/− , Rspo1 −/+ (GhomRhet) and Gadd45g −/− , Rspo1 −/− (double knockout, DKO) fetuses, and controls ( Fig. 3A , B , C , D , E and F ). Examination of Sertoli cell ( Fig. 3A ), Leydig cell ( Fig. 3B ) and meiotic germ cell ( Fig. 3C

Open access

Cheryl J Ashworth, Susan O George, Charis O Hogg, Yu-Ting Lai, and Paula J Brunton

with testicular cords formed on day 16, differentiation of Leydig cells occurring on day 17 and the first wave of Sertoli and Leydig cell proliferation occurring during late foetal life ( Orth 1982 ). Foetal testes secrete testosterone, which reaches a

Open access

Yayoi Obata, Takuya Wakai, Satoshi Hara, and Tomohiro Kono

). Prior to the sex differentiation of germ cells, Sry and Sox9 are expressed in the somatic cells in the male gonad, which leads to testes cord formation and Sertoli and Leydig cell differentiation ( Kashimada & Koopman 2010 ). Adams & McLaren (2002

Open access

Feng Wang, Zheng Chen, Xiaofang Ren, Ye Tian, Fucheng Wang, Chao Liu, Pengcheng Jin, Zongyue Li, Feixiong Zhang, and Baochang Zhu

the oocyte during fertilization. The testis contains multiple cell types, including macrophages, peritubular cells, Leydig cells (LCs), Sertoli cells (SCs) and germ cells, which interact to control spermatogenesis ( Majumdar & Bhattacharya 2013