The effect of clomiphene citrate on excretion values for fsh, lh, testosterone and epitestosterone has been investigated in four patients with Klinefelter's syndrome.
During the pretreatment period, levels of fsh and lh were above the normal range for male subjects, while readings of testosterone and epitestosterone were generally low.
Clomiphene produced a significant increase in fsh output in one subject and in lh excretion in another. In the remaining patients, pituitary gonadotrophic function was not affected by the administration of the compound. The effect of clomiphene on excretion values for C-19 steroids was inconsistent.
The study did not provide definite evidence regarding the site of of action of clomiphene in patients with Klinefelter's syndrome.