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Although the evidence for the presence of adrenergic alpha and beta receptors in the uterus is fairly conclusive (Ahlquist, 1948; Wansbrough, Nakanishi & Wood, 1968) their significance in normal pregnancy is not known. Levy & Tozzi (1965) have demonstrated that the effect of adrenaline on the uterus could be inhibited by compounds possessing some degree of beta adrenergic receptor blocking effect. In the present investigation, the effect of administration of the beta-blocking agent, propranolol, alone, the alpha-blocking agent, dibenzyline, alone, and propranolol and dibenzyline together has been studied on implantation in three groups of normal pregnant rats. The drugs were administered on Days 1 to 4 of pregnancy in the first series of experiments and on Days 2 to 5 in the second series of experiments. The latter series of experiments was
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Changes in the pattern of cell division in the rat uterus with an intra-uterine silk thread suture in one horn were studied during the first 5 days of pregnancy.

There was no appreciable difference between the mitotic counts in the two horns on Days 1 to 4 of pregnancy, except that there was an increase in the luminal epithelial mitotic count on Day 4 of pregnancy in the horn with the device.

There was a marked difference in the luminal mitotic count between the two horns on Days 4 and 5 of pregnancy. While the mean mitotic count was 1·7 in the control horn on Day 5, it was 421 in the horn with the device. The diminution in the mitotic count seen on Day 5 of pregnancy in the control horn was not present in the horn with the device. It is possible that the effect of endogenous progesterone in causing diminished mitosis in the lumen was prevented by the presence of an IUD.