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Katuhide Tanaka and M. Kamiyoshi

Department of Poultry and Animal Sciences, Gifu University, Kakamigahara, Gifu, Japan

Fujino et al. (1972) have synthesized a nonapeptide amide with the structure, (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-ethylamine, which is an analogue of LH-RH. This analogue has been shown to be more effective than LH-RH in causing the release of LH and FSH from the pituitary of rats (Fujino et al., 1972; Arimura, Vilchez-Martinez & Schally, 1974) and man (Nakano, Takekida, Kotsuji, Miyazaki & Tojo, 1974), and in inducing ovulation in rats and rabbits (Fujino et al., 1973). This paper reports a comparison of the ovulation-inducing activity in hens between synthetic LH-RH and the analogue.

The synthetic LH-RH (Eisai Co. Ltd, Tokyo, Japan) and the analogue (Takeda Chemical Industries, Tokyo, Japan) were dissolved in sterilized distilled water. They were injected into the pectoral muscle of White Leghorn hens (2·0-2·4 kg body wt, 17 months of age) which had been laying eggs in a regular

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Injections of a mixture of fsh and lh into hens caused premature ovulation although each hormone was ineffective when injected alone at the same dose level. The incidence of premature ovulation increased when an ineffective dose of fsh was given with a mildly effective dose of lh. The increase was also found when fsh was injected either immediately after or 1 hr after the injection of lh. The results suggest that fsh augments the action of lh to induce ovulation in the hen.