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A. ABDEL-AZIZ and N. BAKRY

Summary.

The reactivity of the isolated rat uterus to isoprenaline, adrenaline, noradrenaline and phenylephrine was investigated during the different phases of the oestrous cycle, after oestradiol administration, during pregnancy, and after parturition.

There was no significant difference between the reactivity to any one of the four sympathomimetic agents during the different phases of the oestrous cycle. Oestradiol administration significantly decreased the sensitivity of the uterus to noradrenaline and phenylephrine when compared with natural oestrus. The decrease in the case of adrenaline was not significant, and reactivity to isoprenaline did not change following oestrogen administration.

Reactivity to the four agents decreased markedly during pregnancy and returned to normal between the 4th and the 7th day after parturition. The decrease in the reactivity of the uterus to the inhibitory action of some sympathomimetic agents is oestrogen-linked, and most probably due to the appearance of α-adrenergic excitatory receptors. Other factors which may have contributed to changes in reactivity to such agents are discussed.

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A. ABDEL-AZIZ, A. GHAZAL and TAHIA DAABEES

Summary.

The effect of oral treatment of rats for 12 consecutive days with the contraceptive steroids, mestranol (0·08 mg/rat/day) and lynoestrenol (2·5 mg/rat/day), separately or in combination, on the sensitivity of the isolated spontaneously contracting rat uterus to the inhibitory action of isoprenaline, adrenaline and noradrenaline was investigated. The sensitivity to isoprenaline did not change significantly after any of the hormonal treatments. The sensitivity to adrenaline was significantly reduced after treatment with mestranol and lynoestrenol separately and together. Only mestranol treatment also resulted in a significant decrease in sensitivity to noradrenaline while the decrease after lynoestrenol or mestranol+lynoestrenol was not significant. Treatment with only one or with a combination of the steroids resulted in the appearance of excitatory α-adrenoceptors which most probably contributed to the decrease in the sensitivity of the uterus to the inhibitory action of the sympathomimetic agents.

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A. ABDEL-AZIZ, A. GHAZAL and TAHIA DAABEES

Summary.

The effect of oral treatment of rats for 12 days with the contraceptive steroids, mestranol (0·08 mg/rat/day) and lynoestrenol (2·5 mg/rat/day) alone and in combination, on ovarian histamine content was studied. All treatments resulted in a decrease in the histamine content per ovary, but this was only significant for mestranol alone. When the results were expressed in terms of histamine per g ovary, treatment with mestranol resulted in a significant decrease while lynoestrenol and mestranol plus lynoestrenol treatment resulted in a non-significant increase.

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A. ABDEL-AZIZ, A. GHAZAL, TAHIA DAABEES and I. LOUTFI

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria,Alexandria, Egypt Arab Republic

(Received 1st July 1974)

Shelesnyak (1959) first suggested that histamine might be the inducing factor for decidualization and that it might be involved in the process of implantation in the rat (Shelesnyak & Kraicer, 1964). Treatment with oestrogen results in histamine depletion from the rat uterus (Szego, 1966; McKercher, Van Orden, Bhatnagar & Burke, 1973), and it was suggested that histamine might be involved in the hyperaemia and oedema stimulated by oestrogen (Szego, 1966). Recently, it has been reported that treatment with the contraceptive steroids, mestranol and lynoestrenol, alone or in combination, resulted in a decrease in histamine content per ovary in the rat (Abdel-Aziz, Ghazal & Daabees, 1974). The present work was undertaken to study the effect of mestranol and lynoestrenol on the histamine content of the rat uterus.

Fifty-six virgin female albino rats with a