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  • Author: A. D. DICKSON x
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A. D. DICKSON

Summary.

Delayed implantation, after ovariectomy on Day 3 of gestation, was induced in mice by subcutaneous injections of 6α-methyl-17-acetoxyprogesterone on Days 3 and 8 of gestation and of oestradiol benzoate on Day 8. 95% of mice had implantations on Day 12. The mean number of implantations per mouse, 11·3, was not significantly different from the mean in normal controls. Delayed implantation sites were similar in size to those of normal mice when allowance was made for the delay, while the incidence of visibly pathological sites was low. Variations of the technique were less effective.

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A. D. DICKSON

Summary.

Although most mature mouse blastocysts recovered during normal gestation possess trophoblastic giant cells, very few undergoing delayed implantation possess them.

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P. V. HOLMES and A. D. DICKSON

Summary.

A secretion from mouse trophoblast was investigated using the mouse adrenal X-zone, which degenerates differently under the influence of androgens and progestagens. Blastocysts were transplanted under the kidney capsules of female mice and, subsequently, the kidneys and adrenals were examined histologically for trophoblast growth and X-zone degeneration, respectively. Adrenal X-zone degeneration was evident in immature mice only when they received blastocyst transplants, correlating trophoblast proliferation with X-zone degeneration. The degeneration found in both transplanted and control adults correlates maturity with X-zone regression. The fact that the mode of degeneration was always histologically similar to that induced by progestagens implies a progestagenic mediation.