Effects of gonadotrophin administration were investigated histologically in the testes of neonatal mice. The hormones used were human pituitary follicle-stimulating hormone (fsh), containing 20% of luteinizing hormone, and human chorionic gonadotrophin (hcg).
fsh treatment increased the numbers of nuclei of spermatogonia and of Sertoli-cell precursors per mouse and caused an even greater increase in the volume of eosinophilic intratubular material. It is thought that the greater part of this material was syncytial cytoplasm of the Sertoli-cell precursors.
Administration of hcg did not have these effects nor modify the effects of fsh treatment.