Search Results

You are looking at 1 - 7 of 7 items for

  • Author: AMIYA B. KAR x
Clear All Modify Search
Free access

V. P. KAMBOJ and AMIYA B. KAR

Summary.

The effect on the testis of some forty-two water-soluble salts of metals and rare earths was investigated in rats and mice. In general, a single intratesticular injection caused varying degrees of degeneration of the seminiferous epithelium and the interstitium. Thirty-five of the salts tested exerted some degree of antitesticular effect. A single subcutaneous injection was ineffective but continuous administration by the same route caused selective spermatogenic arrest with nine salts. Some of the salts caused aspermia of the recipient animals; others disintegrated the residual spermatozoa in the ductus deferens by separation of the head and tail. The possible mechanism of action of the salts is discussed.

Free access

AMIYA B. KAR, V. P. KAMBOJ and J. K. DATTA

Summary.

The presence of a foreign body in the uterine horn prevented implantation in rats when the process was delayed experimentally for 6 days. The contralateral horn, however, showed normal implantations.

Free access

AMIYA B. KAR, V. P. KAMBOJ and AJIT GOSWAMI

Summary.

A single local injection of ferrous sulphate or ferric chloride causes total destruction of the testis of adult rhesus monkeys. Histochemically, the injected iron is found to be localized in the tunica propria of the tubules and in the interstitium; it accumulates in the mitochondrial and the supernatant fractions almost in equal amounts. It seems that iron causes a generalized damage to the testis through properties common to other heavy metallic ions.

Free access

AJIT GOSWAMI, AMIYA B. KAR and S. R. CHOWDHURY

Summary.

Uterine lipid components of mice were analysed during different stages of the oestrous cycle and after ovariectomy and replacement therapy. During oestrus, and in ovariectomized animals subjected to oestrogen treatment, there was a fall in total lipid concentration and percentage of triglycerides, but an increase in concentration of phospholipids, as compared to the corresponding di-oestrous values. Progesterone antagonized the effect of oestrogen and restored the triglyceride concentration to the di-oestrous level. In comparison, the effect of progesterone on total lipids or phospholipids was less marked. There was no significant change in uterine cholesterol concentration during different stages of the oestrous cycle or after ovariectomy and hormone therapy. In general, the fatty acid components of the lipid constituents showed lower iodine values and increased saturation under the influence of oestrogen. These changes were more evident in triglyceride and phospholipid fractions than in the cholesterol ester fraction. Of the nitrogenous bases of phosphoglycerides, serine showed a more marked increase than the other components. The possible significance of these findings is discussed.

Free access

AMIYA B. KAR, V. P. KAMBOJ and HARISH CHANDRA

Summary.

Antispermatogenic effect of Methallibure (ICI 33828), Tretamine (triethylenemelamine) and Busulphan (1,4-dimethanesulphonoxybutane) was investigated in rhesus monkeys. Methallibure (16 mg/kg for 15 days, orally) had no effect on spermatogenesis, Leydig cells or pituitary gonadotrophic activity. Tretamine (0·05 mg/kg for 30 days, intravenous injection) selectively arrested spermatogenesis at the spermatogonial stage and caused a slight reduction in serum gonadotrophin level. Busulphan (10 mg/kg, single intraperitoneal injection) also suppressed spermatogenesis at the spermatogonial stage but not selectively, since an adverse effect on the interstitium and the accessory genital organs was noted; some reduction in serum gonadotrophin content was also observed. These effects appeared to be reversible. The possible significance of these findings in relation to the modus operandi of these compounds is discussed.

Free access

AMIYA B. KAR, A. R. BOSE and R. P. DAS

Summary.

m-Xylohydroquinone had no effect on the genital organs of male rats. Fertility was unaffected even after persistent administration of the drug.

Free access

AMIYA B. KAR, V. P. KAMBOJ, AJOT GOSWAMI and S. R. CHOWDHURY

Summary.

An intra-uterine suture did not evoke any acute changes in the rat uterus. However, prolonged presence of the suture provoked keratinized metaplasia of the epithelium in 20% of the animals and cystic glandular hyperplasia in 10%. The O2 uptake rate was doubled in the treated horn but other biochemical constituents did not undergo any noteworthy change. Pregnancy was invariably prevented in the treated horn. However, this effect was reversed by removal of the suture provided there were no gross abnormalities in the uterus. Animals fitted with the suture before puberty also conceived only in the control horn when their fertility was tested during adult life. The removal of the suture led to pregnancy in both horns. This indicated that the reproductive potential of these animals was not disturbed due to the insertion of the suture during prepuberal life.