The mammalian oviduct provides the environment for the embryo during its early development. Since oviducal fluid is composed of secretory products and products of transudation (Hamner, 1971), systemically administered compounds might influence the oviducal environment in two ways: (1) by altering the volume and/or chemical composition, and (2) by entering the oviducal fluid directly. The following experiment was performed to evaluate the influence of prostaglandins on embryo development.
Twenty-two New Zealand does were injected intramuscularly with 150 i.u. PMSG (Ayerst Laboratories, Inc.) 72 hr before being mated naturally or artificially inseminated. Immediately after insemination, all does were injected intravenously with 100 i.u. HCG (Sigma Chemical Co.) and, 6 to 7 hr later, both oviducts were ligated with silk sutures at the uterotubal junction. Because of the reported effects of prostaglandins on egg transport (Ellinger & Kirton, 1972;