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EARL PARR

Summary.

Measurements of histamine in control and IUCD-containing uterine horns of the rat in di-oestrus and L4 of pregnancy showed that device-containing horns had a higher concentration and content per horn than did control horns at both times. In control horns, the histamine content on L4 was about one-half of the value observed in di-oestrus, while in IUCD-containing horns the histamine content on L4 was the same as the di-oestrous value. These data are interpreted in terms of a chronic inflammatory response in the IUCD-containing horn.

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EARL PARR

Summary.

Foreign bodies in the uteri of germ-free and conventional rats caused a weight increase only in those portions of the uterus where there was an inflammatory reaction. In oestrogen-deprived, conventional animals, uterine inflammation prevented involution and the disappearance of nucleoli from the endometrium. It appears that inflammation is responsible for the weight increase in uteri containing foreign bodies. It is suggested that inflammation may also be responsible for the luteolytic effect of uterine foreign bodies.