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  • Author: ERIC W. HAHN x
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Modification of the vaginal oestrous cycle is a well-documented sequel to irradiation of the common laboratory mammals. In general, irradiated females experience a period of fairly regular oestrous cycles, followed by a reduction or cessation of cycling (Parkes, 1927; Genther, 1931; Shapiro & Nuzdin, 1958; Slate & Bradbury, 1962). In less severely irradiated animals, an eventual return to normal cycling has been reported (Geist, Gaines & Escher, 1941; Bischoff, Ullmann & Ingraham, 1944). Oestrous cycle depression is characterized by prolongation of vaginal cornification, leading to constant cornification and finally permanent di-oestrus (Mandl, 1959a; Plagge & Krehbiel, 1962; Slate & Bradbury, 1962). While X-ray-induced changes in vaginal oestrus have been described in considerable detail, very little information is available concerning the pattern of psychological and physiological oestrus in irradiated animals. Exposure of rats during metoestrus to 50 to 200 R X-rays has been found to induce typical signs of