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F. J. ZELLER

The possibility that dihydrotestosterone (DHT) may be the intracellular active form of testosterone (Bruchovsky & Wilson, 1968) has led to many investigations of their effects on reproductive structures in both sexes (Gloyna & Wilson, 1969; Gonzalez-Diddi, Komisaruk & Beyer, 1972). In this communication, the synergistic effects of testosterone propionate (TP) and DHT on oestradiol stimulation of the immature chick oviduct are compared.

Single-comb White Leghorn fowl, 12 to 15 days old at the start of the experiments, were used. Birds were the same age in any one experiment. The steroids (TP, DHT and oestradiol benzoate or dipropionate) were suspended in sesame oil and injected subcutaneously for 7 days. All animals, including the controls, received 0·1 ml sesame oil/day. At autopsy, the combs and oviducts were quickly removed and weighed to the nearest mg. Comb data are presented to

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F. J. ZELLER

The suggestion has been made in recent years that dihydrotestosterone (DHT : 17 β-hydroxy-5α-androstan-3-one) may be the biologically active form of testosterone in a variety of target organs. The chick comb, for example, achieves an appreciable conversion of testosterone to DHT (Gloyna & Wilson, 1969). With this in mind, several experiments were performed to compare the actions of testosterone propionate (TP) and DHT in the fowl, using comb weight, testis weight, anterior pituitary weight and gonadotrophin content as end-points for androgen activity.

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Single comb, White Leghorn fowl were used in the experiments and the steroids (TP and DHT) were suspended in sesame oil. At autopsy, the glands were quickly removed and weighed. The anterior pituitary glands were stored in acetone for total gonadotrophin assay or were homogenized in cold distilled