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  • Author: GUY H. KIRACOFE x
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GUY H. KIRACOFE and HAROLD G. SPIES

Summary.

Regression of the corpora lutea was hastened in hysterectomized-pseudopregnant rats by parabiotic union with ovariectomized partners. Hysterectomized-pseudopregnant rats paired either with hysterectomized-pseudopregnant or with normal cycling partners had periods of pseudopregnancy similar in length to those in unpaired hysterectomized-pseudopregnant control females. Injections of ether-soluble extracts or of lyophilized homogenates of oestrous rat uteri did not shorten pseudopregnancy in hysterectomized rats.

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GUY H. KIRACOFE and HAROLD G. SPIES

Summary.

Hysterectomy in ewes 3 to 6 days post-oestrus resulted in prolonged corpora lutea maintenance; luteal regression, however, had occurred by about 150 days post-oestrus. Hysterectomized ewes reovulated after luteal regression and maintained the resulting corpora lutea for a similar period of time. Corpora lutea induced with exogenous gonadotrophins after hysterectomy regressed asynchronously with naturally formed corpora lutea present at the time of the induced ovulation, and the significance of this is discussed.

Hysterectomy during anoestrus resulted in ovulation without oestrus and maintenance of subsequent corpora lutea.

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GUY H. KIRACOFE, A. R. SINGH and N. D. NGHIEM

Summary.

Rabbit antiserum to sheep lh inhibited uterine growth in adult rats following uterine trauma on Day 4 of pseudopregnancy. The weights of the horns subjected to trauma were similar to those obtained in rats ovariectomized at the time of trauma and given only progesterone, and in rats with the adenohypophysis transplanted beneath the kidney capsule on the day of ovulation. Antiserum to lh given to rats with an autotransplanted pituitary did not alter decidual growth. Oestrone restored maximal uterine growth in rats receiving lh antiserum and in rats with an autotransplanted pituitary. Simultaneous injections of fsh and lh resulted in maximal decidual cell response in pituitary autotransplanted rats, while either, given alone, had only slight stimulatory effects. It is suggested that lh antiserum inhibits the oestrogen production necessary for maximal uterine growth. Luteinizing hormone does not appear to be necessary, unless in minute quantity, for production of progesterone in amounts large enough to support maximal uterine growth after trauma.