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H. W. HAWK, T. H. BRINSFIELD and H. F. RIGHTER

Summary.

Vascular permeability in uterine endometrium and serosa was measured in eighty-three ewes by the intensity of tissue blueing after intravenous injection of trypan blue dye. Permeability was high in oestrous ewes, intermediate in luteal-phase ewes and low in ovariectomized controls.

During experimental acute infection in the uterine lumen, endometrial vascular permeability increased greatly in ovariectomized ewes, but little or not at all in luteal-phase or oestrous ewes, indicating that endogenous ovarian hormones modified the vascular response. Serosal vascular permeability increased markedly in ewes of each endocrine state. Endocrine-controlled variation in the rate of leucocytic emigration was not entirely related to endometrial vascular permeability.

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T. H. BRINSFIELD, H. W. HAWK and H. F. RIGHTER

Summary.

Acute leucocytic responses to Escherichia coli placed in the uterine lumen were inhibited in oestrous ewes. The response was stimulated in ovariectomized ewes when they were injected with oestradiol, and was inhibited when they were injected with progesterone or with oestradiol and progesterone simultaneously. Uteri of ovariectomized ewes injected with both hormones were similar to those of oestrous ewes, being short and turgid, with high endometrial vascular porosity to circulating vital dye. The results support the suggestion that the inhibition of induced leucocytic emigration in the oestrous sheep uterus may be due to endogenous progestagen.