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H. P. Bugge and L. Plöen

Summary. Volume density of Sertoli cells in mature rats was estimated in different stages of the cycle of the seminiferous epithelium. Manual point-counting on electron micrograph montages revealed a more than 40% increase in Sertoli cell volume from just before to just after spermiation. It is suggested that this variation should be considered in studies of stage-dependent cyclic variations in activity of Sertoli cells and/or germ cells.