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J. L. BRUN and A. PSYCHOYOS

Exposure of mouse blastocysts in vitro to acidified media effective in dissolving the zona pellucida (Gwatkin, 1964), was reported to be incompatible with the survival of the blastocyst (Bowman & McLaren, 1969). It has been concluded that decreased pH is unlikely to be responsible for the lysis of the zona pellucida in utero (Bowman & McLaren, 1970). This conclusion was drawn from data concerning the effect of a prolonged exposure (up to several hours) of eggs to acidity in vitro. Evidence is reported here to show that the dissolution of the zona pellucida by a brief exposure of the blastocyst to acidity is compatible with its viability and subsequent development.

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V. BITTON-CASIMIRI, J. L. BRUN and A. PSYCHOYOS

Summary.

Rat blastocysts, flushed from the uterus at the moment of the initiation of the implantation process and observed in vitro by time-lapse cinematography, were seen to undergo a series of contractions and dilatations. By these movements, vesicles, containing granular material, emerged through the zona pellucida into the culture medium.

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V. Bitton-Casimiri, J. L. Brun and A. Psychoyos

Laboratoire de Physiologie de la Reproduction, CNRS, E.R. 122, Hôpital de Bicêtre (INSERM), 94270 Bicêtre, France