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HARRY W. RUDEL, MANUEL MAQUEO and JORGE MARTINEZ-MANAUTOU

Summary.

Chlormadinone, an orally active progestagen, was administered in conjunction with an oestrogen to normally menstruating and to postmenopausal women, and the changes induced in the uterine endometrium are described. The effects are not governed solely by the nature of the progestagen, but are directly related to the proliferative state of the endometrium at the start of treatment.

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HARRY W. RUDEL, THOMAS LEBHERZ, MANUEL MAQUEO-TOPETE, JORGE MARTINEZ-MANAUTOU and STUART BESSLER

Summary.

An assay to determine the anti-oestrogenic potency of progestagens in women is described. The progressive increase in endometrial glandular suppression with increasing doses of progestagens is the basis of the assay. Norethindrone (oestrogen free) is three times as potent as chlormadinone acetate with a 95% confidence limit of 2·3 to 4·0. This is in contrast to the greater secretory potency of chlormadinone acetate. It is suggested that the anti-oestrogenic action of progestagens is of some importance in the selection of compounds for contraceptives of the combined progestagen—oestrogen, and of great importance for those of the continuous low dose progestagen types. This property may also be desirable in the treatment of both endometrial hyperplasia and adenocarcinoma.