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Pan-Pan Cheng Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Jun-Jie Xia Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Hai-Long Wang Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Ji-Bing Chen Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Fei-Yu Wang Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Ye Zhang Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Xin Huang Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Quan-Jun Zhang Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Zhong-Quan Qi Organ Transplantation Institute of Xiamen University, Basic Medical Department of Medical College, The Yanwu Branch of Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province 361005, People's Republic of China

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Maternal diabetes adversely affects preimplantation embryo development and oocyte maturation. Thus, it is important to identify ways to eliminate the effects of maternal diabetes on preimplantation embryos and oocytes. The objectives of this study were to investigate whether islet transplantation could reverse the effects of diabetes on oocytes. Our results revealed that maternal diabetes induced decreased ovulation; increased the frequency of meiotic spindle defects, chromosome misalignment, and aneuploidy; increased the relative expression levels of Mad2 and Bub1; and enhanced the sensitivity of oocytes to parthenogenetic activation. Islet transplantation prevented these detrimental effects. Therefore, we concluded that islet transplantation could reverse the effects of diabetes on oocytes, and that this technique may be useful to treat the fundamental reproductive problems of women with diabetes mellitus.

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