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Chen Yang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Yue Li College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Hai-Yang Pan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Meng-Yuan Li College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Ji-Min Pan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Si-Ting Chen College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Hai-Yi Zhang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zhen-Shan Yang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Hai-Ting Dou College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zeng-Ming Yang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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There are around 300 million adolescent pregnancies worldwide, accounting for 11% of all births worldwide. Accumulating evidence demonstrates that many adverse perinatal outcomes are associated with adolescent pregnancies. However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice. We found that the litter size of adolescent pregnancy is significantly decreased from F1 to F3 generations compared to mature pregnancy. On days 8 and 12 of pregnancy, multiple abnormalities in decidual and placental development appear in F3 adolescent pregnancy. On days 5 and 8, uterine endoplasmic reticulum stress is dysregulated in F3 adolescent pregnancy. Embryo implantation and decidualization are also compromised in adolescent pregnancy. Many genes are abnormally expressed in adolescent estrous uteri. The abnormal endocrine environment and abnormal implantation from uterine immaturity may result in multiple pregnancy failures in adolescent pregnancy. The aim of this study is to shed light on human adolescent pregnancy.

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