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S. K. BATTA and R. R. CHAUDHURY

Summary.

The intraluminal fluid from the rat uterus with an intrauterine silk thread suture exerts an anti-implantation effect when administered intraluminally into the uterus of a recipient rat on Day 2 and Day 4 but not on Day 6 of pregnancy. It is suggested that the intra-uterine device exerts its antifertility effect by release of a pharmacologically active agent.

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S. K. SAKSENA and R. R. CHAUDHURY

Summary.

One of the aza-analogues, 7,8,9,10-tetrahydro-7-oxo-benzo (c) phenanthridine exhibited an anti-androgenic activity on immature, castrated, male rats. The compound had an interesting anti-androgenic activity as the effect of testosterone-induced gain in weight of the ventral prostate was significantly inhibited by the compound. This compound did not, however, inhibit the androgen-induced weight increase of the seminal vesicle.

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S. K. BATTA and R. R. CHAUDHURY

Summary.

In rats provided with a surgically created anastomosis between the two uterine horns and subsequently mated, implantation occurs with great regularity. Implantation sites were seen in twenty-six out of the thirty-two rats examined at laparotomy on Day 10 of pregnancy.

In rats with such an anastomosis and unilaterally ovariectomized, implantation occurred in both uterine horns. There was evidence of implantation in nine out of twelve rats in the left uterine horn, even though the left ovary had been removed, indicating that the anastomosis was patent.

Out of fifteen successfully mated rats with a connection between the two uterine horns and a silk suture in the lumen of the left uterine horn, only one rat showed evidence of implantation in the left uterine horn on Day 10 of pregnancy. There were no signs of implantation sites in the right horn in any animal in this series. The results demonstrated inhibition of implantation in the control horn when an intra-uterine device was placed in the experimental horn in rats with an anastomosis between the two horns. This suggests that the presence of a device in one horn led to the liberation of a substance which passed to the control horn through the surgically created anastomosis and there prevented implantation.

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S. K. SAKSENA and R. R. CHAUDHURY

Summary.

Nine azasteroids have been evaluated for antifertility effect in rats when fed orally from Days 1 to 4 of pregnancy at the dose of 10 mg/kg body weight. The compounds 3β-hydroxy-androst-5-ene (16, 17-C)-5-methyl-pyrazole and 1,2,3,4-tetrahydro-N-tosyl-8-methoxy-4-oxo-benzo(b)quinoline inhibited pregnancy at that dose in a significant number of rats.

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R. R. CHAUDHURY, S. K. SAKSENA and S. K. GARG

Taxus baccata Linn., a tree which grows abundantly in India, has been reported to possess an antifertility effect (Kirtikar & Basu, 1935; Chopra, Nayar & Chopra, 1956; Chopra, Chopra, Handa & Kapoor, 1958; Chaudhury, 1966). Khanna, Garg, Vohora, Walia & Chaudhury (1969) recently reported that anti-implantation activity is present in the leaves. Possible anti-ovulatory activity of different extracts of leaves of Taxus baccata has been screened on fifty-eight, adult, non-pregnant rabbits, each weighing between 1·5 and 2·0 kg. The rabbits were obtained from a local source and housed in independent cages for at least 3 weeks before use.

The air-dried, powdered leaves of Taxus baccata were successively extracted with petroleum ether (b.p. 60 to 80° C), alcohol (95 %) and distilled water and the extracts were administered as a suspension with

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U Sharma, K Chaudhury, NR Jagannathan and SK Guha

Nuclear magnetic resonance (NMR) spectroscopy was used to quantify citrate, glucose, lactate, glycerophosphorylcholine and choline in seminal plasma from subjects injected with a new male contraceptive RISUG, a copolymer of styrene maleic anhydride dissolved in dimethyl sulphoxide, and in seminal plasma from normal ejaculates. No significant difference in the concentration of citrate was observed between the groups, indicating that the prostate is not affected by the contraceptive. The concentrations of glucose, lactate, glycerophosphorylcholine and choline were significantly lower (P < 0.01) in subjects injected with RISUG compared with controls. In addition, metabolite ratios such as choline:citrate, citrate:lactate, choline:lactate and glycerophosphorylcholine:choline were calculated. Citrate:lactate and glycerophosphorylcholine:choline ratios were significantly lower in RISUG-injected subjects than in controls (P < 0.01), thereby indicating the occurrence of partial obstructive azoospermia. The most important finding of the present study was that the intervention of RISUG in the vas deferens even for a period as long as 8 years is absolutely safe and does not lead to prostatic diseases.