It has frequently been suggested that the peripheral nervous system plays a part in the process of implantation and early pregnancy. Evidence for this was proposed by Nalbandov & St. Clair (1958) but much of this evidence is now open to alternative explanations (Anderson, Bland & Melampy, 1969). The study of implantation in a transplanted uterus would clarify the situation but attempts in the sheep have been unsuccessful (Niswender, Dziuk, Graber & Kaltenbach, 1970). Transplantation of the uterus ensures complete isolation from its original nerve supply and any reinnervation is almost certainly nonspecific.
Two-stage uterine autotransplantation was performed in five guinea-pigs by the method described by Bland (1970). The first stage involved the severing of the broad ligament down the entire length of both uterine horns and then suturing the mesometrial aspect of the uterus to the muscle of the body wall. When the animal had returned normally to