Search Results
You are looking at 1 - 2 of 2 items for
- Author: Kailai Cai x
- Refine by access: All content x
Search for other papers by Kailai Cai in
Google Scholar
PubMed
Search for other papers by Guohua Hua in
Google Scholar
PubMed
Search for other papers by Li Han in
Google Scholar
PubMed
Search for other papers by Xiang Li in
Google Scholar
PubMed
Search for other papers by Liguo Yang in
Google Scholar
PubMed
Metabolomics and Proteomics Technology Platform, West China Hospital, Sichuan University, Chengdu, PR China
Search for other papers by Wen Zheng in
Google Scholar
PubMed
Search for other papers by Liang Zhang in
Google Scholar
PubMed
Search for other papers by Kailai Cai in
Google Scholar
PubMed
Search for other papers by Kongju Wu in
Google Scholar
PubMed
Search for other papers by Ge Liang in
Google Scholar
PubMed
Search for other papers by Lu Zhang in
Google Scholar
PubMed
Search for other papers by Lihui Liao in
Google Scholar
PubMed
Search for other papers by Fujun Shen in
Google Scholar
PubMed
Search for other papers by Wenping Zhang in
Google Scholar
PubMed
Search for other papers by Li Wang in
Google Scholar
PubMed
Search for other papers by Yan Li in
Google Scholar
PubMed
Search for other papers by Ye Wang in
Google Scholar
PubMed
Search for other papers by Jie Kou in
Google Scholar
PubMed
Search for other papers by Yi Zhong in
Google Scholar
PubMed
Search for other papers by Xin Li in
Google Scholar
PubMed
Search for other papers by Jingqiu Cheng in
Google Scholar
PubMed
Search for other papers by Meng Gong in
Google Scholar
PubMed
Search for other papers by Rong Hou in
Google Scholar
PubMed
In brief
The metabolic processes of the gestation period in pandas remain poorly understood. Our study comprehensively characterizes the metabolism of giant pandas during gestation and proposes arginine and histidine as potential novel biomarkers for detecting the pregnancy state of giant pandas.
Abstract
There has been remarkable progress in the conservation and reproduction of giant pandas. However, the physiology of the gestation period in pandas remains poorly understood. The metabolic processes from estrus to pregnancy are dynamic and precisely regulated, playing a crucial role in pregnancy and related dysfunctions. In this study, we conducted a metabolomic analysis of 37 blood samples collected from pandas in estrus, acyclic, and potential pregnant states, employing rigorous screening to minimize the influence of diet. Our findings suggest that a reduced appetite can serve as an indicator for evaluating implantation time, representing a characteristic response to pregnancy and aiding in the prediction of delivery time in pregnant pandas. Metabolomic results indicate great metabolism variation from estrus to pregnancy, highlighting the association between amino acid metabolism and pregnancy outcomes. Compared to other pandas, individuals who successfully bred exhibit significantly elevated levels of arginine and histidine, even 2 months before experiencing a reduced appetite. Furthermore, the lipid profile undergoes distinct dynamic changes only in estrus samples. In summary, our study comprehensively characterizes the metabolism of giant pandas during gestation and proposes arginine and histidine as potential novel biomarkers for detecting the pregnancy state of giant pandas.