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L. MONDORF and M. FABER

Summary.

The number of children born to 180 females exposed to abdominal fluoroscopy in connection with an attack of intussusception in infancy or childhood was compared to the number born to women who were treated for the same disease without fluoroscopy.

No difference was found between the number of children born or the age distribution of birth between the two groups. The significance in relation to the known radiation sensitivity of mice is discussed. The sex ratio in this and a comparable series shows an unexpected though statistically non-significant increase in male births.

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Mette M. Andersen, J. Krøll, A. G. Byskov and M. Faber

Summary. The proteins in follicular fluid from individual and pooled bovine follicles were studied by gel chromatography and quantitative immunoelectrophoresis. The mean protein concentration was 86·4% of serum; very large proteins were present in only low concentrations. A minimum of 40 individual proteins was distinguished in follicular fluid, and 15 of these proteins were quantitated. A correlation between molecular weight and follicular fluid:serum concentration ratio was found. Fluid from individual follicles differed only in the relative concentrations of small and large proteins. An exception to this was IgG which was occasionally, but never in healthy growing follicles, present in concentrations above 150% of serum. Healthy growing, preovulatory and atretic follicles had higher, and cystic follicles mostly lower, concentrations of small proteins than serum. The concentration of α2-macroglobulin in healthy growing follicles never exceeded 16% of serum. The concentration of large proteins in follicular fluid increased with increasing follicle size.

Attempts to detect proteins specific to follicular fluid by immunizing rabbits with pooled follicular samples and the follicular fluid proteins not bound by anti-bovine antiserum resulted in production of antibodies against fibrinogen and its split products D + E only.

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H. PETERS, A. G. BYSKOV, S. LINTERN-MOORE, M. FABER and M. ANDERSEN

Summary.

The injection of gonadotrophin (PMSG) into mice between the ages of 3 and 6 days did not alter the number of follicles that started growth, suggesting that it did not provide the stimulus to small follicles to start their development. The injection of PMSG had no influence on small oocyte atresia.

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SUE LINTERN-MOORE, HANNAH PETERS, G. P. M. MOORE and M. FABER

Summary.

The morphology and growth pattern of human ovarian follicles has been studied between birth and 9 years of age. Follicles have been classified according to their morphology, diameter, the diameter of the oocyte and the number of granulosa cells in the widest cross-section. Nine major classes of follicle were recognized. The smallest, Class B follicles, contained a non-growing oocyte and were surrounded by a single layer of flattened granulosa cells. The largest, Class F follicles, which were up to 6 mm in diameter, contained an oocyte which had completed growth (80 μm) and a large fluid-filled antrum. The range of follicles and the pattern of oocyte growth in relation to follicle growth found in the ovary was independent of age during childhood.

Follicular growth and atresia are discussed in the light of current concepts of gonadal and pituitary function during infancy and childhood.