Search Results
You are looking at 1 - 1 of 1 items for
- Author: Marie-Ève Brien x
- Refine by access: All content x
Department of Pharmacology, Université de Montréal, Montreal, Quebec, Canada
Search for other papers by Mathieu Nadeau-Vallée in
Google Scholar
PubMed
Search for other papers by Dima Obari in
Google Scholar
PubMed
Search for other papers by Julia Palacios in
Google Scholar
PubMed
Department of Microbiology, Virology and Immunology, Université de Montréal, Montreal, Quebec, Canada
Search for other papers by Marie-Ève Brien in
Google Scholar
PubMed
Search for other papers by Cyntia Duval in
Google Scholar
PubMed
Department of Pharmacology, Université de Montréal, Montreal, Quebec, Canada
Search for other papers by Sylvain Chemtob in
Google Scholar
PubMed
Department of Obstetrics & Gynecology, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
Department of Microbiology, Virology and Immunology, Université de Montréal, Montreal, Quebec, Canada
Search for other papers by Sylvie Girard in
Google Scholar
PubMed
Inflammation is essential for successful embryo implantation, pregnancy maintenance and delivery. In the last decade, important advances have been made in regard to endogenous, and therefore non-infectious, initiators of inflammation, which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs), and their involvement in reproduction has only recently been unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating effect on pregnancy outcomes. Many DAMPs, such as uric acid, high-mobility group box 1 (HMGB1), interleukin (IL)-1 and cell-free fetal DNA, have been associated with pregnancy complications, such as miscarriages, preeclampsia and preterm birth in preclinical models and in humans. However, the specific contribution of alarmins to these conditions is still under debate, as currently there is lack of information on their mechanism of action. In this review, we discuss the role of sterile inflammation in reproduction, including early implantation and pregnancy complications. Particularly, we focus on major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA (especially that of fetal origin) while giving an overview of the potential role of other candidate alarmins.
