A recent publication has demonstrated the usefulness of Japanese quail in the detailed investigation of male antifertility chemicals (Jones, Kominkova & Jackson, 1972). The present study describes the effect on quail fertility of various dose levels of two compounds, busulphan (Myleran) and cyclohexane-1,4-diol dimethanesulphonate. Because of the established antispermatogonial actions of these substances in the rat, it was anticipated that an estimate of the duration of spermatogenesis in the avian species would emerge from the present work.
The fertility procedure adopted for these experiments has recently been described (Jones et al., 1972). Myleran, suspended in arachis oil, was administered to groups of four male birds as a single intraperitoneal dose or daily for 5 consecutive days. Cyclohexane-1,4-diol dimethanesulphonate (Jackson, 1971) was administered orally on 5 consecutive days in the same