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KRISTEN B. EIK-NES and PETER F. HALL

Summary.

Pregnant mare serum (pms) increased the secretion of testosterone and the incorporation of acetate-1-14C into testosterone-14C when administered intravenously to anaesthetized dogs, whether the pms was given as a single rapid injection or by continuous infusion during a period of 60 min. When pms was added to slices of rabbit testis in vitro, it increased both the incorporation of acetate-1-14C into testosterone14C and the synthesis of testosterone as shown by measurements of radioactivity and mass of testosterone-14C. It is therefore concluded that pms is capable of increasing the biosynthesis oftestosterone by testicular tissue and that the response of the testis to pms is qualitatively the same as that to interstitial cell-stimulating hormone.